This web server provides online access to a series of tools
developed by the Freiburg Bioinformatics Group.
To start using it, please select from the listings below,
or use the menu on the left. If you prefer doing a
local installation on your machine, please visit our
If you use our tools for research or education, please
the corresponding articles from the
CPSP (Constraint-based Protein Structure Prediction)
is an exact and efficient approach to identify optimal structures
of lattice proteins within the hydrophobic-polar (HP) model. The
approach enables structure prediction within the 3D cubic and
3D face-centered-cubic (FCC) lattice for both backbone-only as well
as side-chain representing models.
HPstruct implements the CPSP approach, as introduced
by Backofen and Will (2006), to predict provably optimal
structures of 3D lattice proteins in the HP-model.
For a given HP-sequence and a given lattice type
(cubic or face centered cubic), (all) optimal structures
are calculated. The CPSP approach computes the global minimal
energy for the input sequence.
HPview allows for the interactive visualization of
lattice protein structures in the HP-model.
LatFit calculates a low deviation on-lattice model of a given full atom
protein structure in Protein Data Base (PDB) format. It utilizes a greedy distance
or coordinate RMSD optimizating approach while successively fitting the structures
monomers on the lattice. It supports backbone-only and sidechain-including models
within various lattices.